1
From: "Human Potential & Development."
Split Justification: Development fundamentally involves both our inner landscape (**Internal World**) and our interaction with everything outside us (**External World**). (Ref: Subject-Object Distinction)..
2
From: "Internal World (The Self)"
Split Justification: The Internal World involves both mental processes (**Cognitive Sphere**) and physical experiences (**Somatic Sphere**). (Ref: Mind-Body Distinction)
3
From: "Somatic Sphere"
Split Justification: The Somatic Sphere encompasses all physical aspects of the self. These can be fundamentally divided based on whether they are directly accessible to conscious awareness and subjective experience (e.g., pain, touch, proprioception) or whether they operate autonomously and beneath the threshold of conscious perception (e.g., heart rate, digestion, cellular metabolism). Every bodily sensation, state, or process falls into one of these two categories, making them mutually exclusive and comprehensively exhaustive.
4
From: "Autonomic & Unconscious Somatic Processes"
Split Justification: ** All unconscious somatic processes are fundamentally regulated through either the dedicated neural pathways of the autonomic nervous system or through the intrinsic, self-regulating mechanisms of other physiological systems (e.g., endocrine, immune, cellular, local tissue systems). These two categories comprehensively cover all autonomous and unconscious bodily functions and are mutually exclusive in their primary regulatory mechanism.
5
From: "Non-Neural Autonomous Physiological Processes"
Split Justification: Non-neural autonomous physiological processes can be fundamentally divided based on the scale and transport mechanism of their primary regulatory signals. One category encompasses regulation achieved through chemical messengers (such as hormones, circulating cytokines, or antibodies) that are transported via body fluids (blood, lymph, interstitial fluid) to exert widespread or distant effects throughout the organism. The other category comprises processes that are intrinsic to the cell or local tissue itself, relying on internal cellular mechanisms (e.g., metabolism, gene expression), direct physical or chemical responses within the immediate tissue environment, or paracrine/autocrine signaling confined to the immediate vicinity, without requiring systemic transport for their primary regulatory action. These two categories are mutually exclusive, as a regulatory mechanism either relies on systemic transport for its primary action or it does not, and together they comprehensively cover all non-neural autonomous physiological processes.
6
From: "Systemic Humoral Regulation"
Split Justification: Systemic humoral regulation is fundamentally mediated by either hormones, which are chemical messengers predominantly secreted by endocrine glands to regulate diverse physiological processes like metabolism, growth, and reproduction; or by immune factors (such as cytokines and antibodies), which are chemical messengers primarily produced by immune cells to coordinate defense, inflammation, and immune surveillance. These two categories represent distinct yet comprehensive regulatory systems, ensuring that all systemic, non-neural chemical signaling is covered, with their primary origins and functional domains being mutually exclusive.
7
From: "Endocrine Hormonal Regulation"
Split Justification: Endocrine hormonal regulation fundamentally serves one of two overarching purposes: either to maintain the internal physiological environment within a stable dynamic range and enable acute adaptations to immediate conditions (homeostatic maintenance), or to drive the orchestrated, often irreversible, changes associated with growth, development, sexual maturation, and reproduction throughout the organism's life cycle (developmental and reproductive progression). These two categories represent distinct and comprehensively exhaustive goals for all endocrine signaling, with any specific regulatory process falling primarily into one domain, ensuring mutual exclusivity.
8
From: "Hormonal Regulation for Homeostatic Maintenance"
Split Justification: ** All endocrine hormonal regulation for homeostatic maintenance can be fundamentally divided based on whether its primary purpose is to manage the body's energy substrates and nutrient levels (e.g., glucose, fat, protein metabolism), or if its primary role is to maintain the body's fluid volume, mineral composition, acid-base balance, and orchestrate systemic responses to physiological stressors. These two categories are mutually exclusive, as a hormone's dominant homeostatic function falls primarily into one domain, and together they comprehensively cover all aspects of acute and dynamic homeostatic regulation performed by the endocrine system.
9
From: "Hormonal Regulation of Fluid, Electrolyte, pH, and Stress Response"
Split Justification: All endocrine hormonal regulation for fluid, electrolyte, pH, and stress response can be fundamentally divided based on whether its primary function is to orchestrate the body's general adaptive response to perceived threats and challenges, leading to widespread physiological adjustments (systemic stress adaptation), or if its primary role is to precisely maintain the dynamic equilibrium of specific internal parameters such as water volume, mineral concentrations, and acid-base balance within physiological limits. These two categories are mutually exclusive, as a hormone's dominant regulatory function falls primarily into one domain, and together they comprehensively cover all aspects of this node.
10
From: "Hormonal Regulation of Systemic Stress Adaptation"
Split Justification: ** All endocrine hormonal regulation for systemic stress adaptation can be fundamentally divided based on whether its primary purpose is to rapidly prepare the body for immediate action in response to an acute, perceived threat (e.g., the 'fight or flight' response), or to mediate the longer-term, sustained physiological adjustments and resource allocation required for coping with chronic or ongoing stressors. These two categories are mutually exclusive in their primary temporal scale and strategic physiological goals, and together they comprehensively cover all forms of systemic hormonal stress adaptation.
11
From: "Hormonal Regulation of Acute Reactive Stress Response"
Split Justification: All endocrine hormonal regulation for acute reactive stress response can be fundamentally divided based on whether its primary purpose is to rapidly mobilize the body's physical and metabolic resources for immediate action (e.g., increased heart rate, blood pressure, glucose release, redirection of blood flow to muscles), or if its primary role is to tune sensory perception and attentional focus to enhance threat assessment and decision-making (e.g., heightened vigilance, altered pain threshold, pupil dilation, increased sensory acuity). These two categories represent distinct and mutually exclusive sets of physiological adjustments, and together they comprehensively cover the body's rapid hormonal preparations for immediate action in response to a perceived threat.
12
From: "Hormonal Regulation of Physical and Metabolic Mobilization"
Split Justification: All endocrine hormonal regulation for physical and metabolic mobilization can be fundamentally divided based on whether its primary purpose is to rapidly increase the availability of metabolic fuels (e.g., glucose, fatty acids, amino acids) in the bloodstream, or if its primary role is to immediately optimize the functional capacity of the cardiovascular, respiratory, and musculoskeletal systems to utilize these fuels and perform physical action. These two categories are mutually exclusive, as a hormone's dominant regulatory effect within this sphere falls primarily into one domain, and together they comprehensively cover all aspects of immediate physical and metabolic resource mobilization during acute stress.
✓
Topic: "Hormonal Regulation of Cardiovascular and Muscular System Activation" (W6285)