1
From: "Human Potential & Development."
Split Justification: Development fundamentally involves both our inner landscape (**Internal World**) and our interaction with everything outside us (**External World**). (Ref: Subject-Object Distinction)..
2
From: "Internal World (The Self)"
Split Justification: The Internal World involves both mental processes (**Cognitive Sphere**) and physical experiences (**Somatic Sphere**). (Ref: Mind-Body Distinction)
3
From: "Somatic Sphere"
Split Justification: The Somatic Sphere encompasses all physical aspects of the self. These can be fundamentally divided based on whether they are directly accessible to conscious awareness and subjective experience (e.g., pain, touch, proprioception) or whether they operate autonomously and beneath the threshold of conscious perception (e.g., heart rate, digestion, cellular metabolism). Every bodily sensation, state, or process falls into one of these two categories, making them mutually exclusive and comprehensively exhaustive.
4
From: "Autonomic & Unconscious Somatic Processes"
Split Justification: ** All unconscious somatic processes are fundamentally regulated through either the dedicated neural pathways of the autonomic nervous system or through the intrinsic, self-regulating mechanisms of other physiological systems (e.g., endocrine, immune, cellular, local tissue systems). These two categories comprehensively cover all autonomous and unconscious bodily functions and are mutually exclusive in their primary regulatory mechanism.
5
From: "Non-Neural Autonomous Physiological Processes"
Split Justification: Non-neural autonomous physiological processes can be fundamentally divided based on the scale and transport mechanism of their primary regulatory signals. One category encompasses regulation achieved through chemical messengers (such as hormones, circulating cytokines, or antibodies) that are transported via body fluids (blood, lymph, interstitial fluid) to exert widespread or distant effects throughout the organism. The other category comprises processes that are intrinsic to the cell or local tissue itself, relying on internal cellular mechanisms (e.g., metabolism, gene expression), direct physical or chemical responses within the immediate tissue environment, or paracrine/autocrine signaling confined to the immediate vicinity, without requiring systemic transport for their primary regulatory action. These two categories are mutually exclusive, as a regulatory mechanism either relies on systemic transport for its primary action or it does not, and together they comprehensively cover all non-neural autonomous physiological processes.
6
From: "Systemic Humoral Regulation"
Split Justification: Systemic humoral regulation is fundamentally mediated by either hormones, which are chemical messengers predominantly secreted by endocrine glands to regulate diverse physiological processes like metabolism, growth, and reproduction; or by immune factors (such as cytokines and antibodies), which are chemical messengers primarily produced by immune cells to coordinate defense, inflammation, and immune surveillance. These two categories represent distinct yet comprehensive regulatory systems, ensuring that all systemic, non-neural chemical signaling is covered, with their primary origins and functional domains being mutually exclusive.
7
From: "Endocrine Hormonal Regulation"
Split Justification: Endocrine hormonal regulation fundamentally serves one of two overarching purposes: either to maintain the internal physiological environment within a stable dynamic range and enable acute adaptations to immediate conditions (homeostatic maintenance), or to drive the orchestrated, often irreversible, changes associated with growth, development, sexual maturation, and reproduction throughout the organism's life cycle (developmental and reproductive progression). These two categories represent distinct and comprehensively exhaustive goals for all endocrine signaling, with any specific regulatory process falling primarily into one domain, ensuring mutual exclusivity.
8
From: "Hormonal Regulation for Homeostatic Maintenance"
Split Justification: ** All endocrine hormonal regulation for homeostatic maintenance can be fundamentally divided based on whether its primary purpose is to manage the body's energy substrates and nutrient levels (e.g., glucose, fat, protein metabolism), or if its primary role is to maintain the body's fluid volume, mineral composition, acid-base balance, and orchestrate systemic responses to physiological stressors. These two categories are mutually exclusive, as a hormone's dominant homeostatic function falls primarily into one domain, and together they comprehensively cover all aspects of acute and dynamic homeostatic regulation performed by the endocrine system.
9
From: "Hormonal Regulation of Metabolic and Nutrient Balance"
Split Justification: All endocrine hormonal regulation for homeostatic metabolic and nutrient balance fundamentally serves one of two primary purposes: either to build up and store complex molecules and energy reserves (anabolism and storage) or to break down and release these stored resources to meet immediate energy and nutrient demands (catabolism and mobilization). These two categories represent opposing yet complementary sets of processes essential for maintaining metabolic equilibrium, and every hormone involved in this domain primarily drives one or the other, ensuring mutual exclusivity and comprehensive coverage of how nutrient and energy balance is hormonally maintained.
10
From: "Hormonal Regulation Promoting Nutrient Catabolism and Mobilization"
Split Justification: ** All endocrine hormonal regulation promoting nutrient catabolism and mobilization fundamentally serves to either increase the availability of glucose (a primary and obligate fuel for certain tissues) or to increase the availability of non-glucose fuels (such as fatty acids) and their precursors (such as amino acids and glycerol). These two categories are mutually exclusive, as the primary mobilized product is either glucose or it is not, and together they comprehensively cover all forms of hormonally regulated nutrient catabolism and mobilization.
11
From: "Hormonal Regulation of Glucose Mobilization"
Split Justification: ** All endocrine hormonal regulation of glucose mobilization fundamentally achieves its purpose through one of two distinct biochemical pathways: either by breaking down stored glycogen into glucose (glycogenolysis) or by synthesizing new glucose from non-carbohydrate precursors (gluconeogenesis). These two processes are mutually exclusive in the origin of the mobilized glucose and together represent all primary physiological mechanisms by which the body acutely increases circulating glucose levels.
12
From: "Hormonal Regulation of Gluconeogenesis"
Split Justification: All endocrine hormonal regulation of gluconeogenesis fundamentally targets the biochemical pathways occurring within one of the body's two primary organs capable of significant glucose production from non-carbohydrate precursors: the liver or the kidneys. These two sites represent distinct anatomical locations where gluconeogenesis takes place, respond with varying capacities and priorities to hormonal signals, and together account for the vast majority of regulated glucose synthesis, ensuring mutual exclusivity based on the organ of action and comprehensive coverage of physiological gluconeogenesis.
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Topic: "Hormonal Regulation of Renal Gluconeogenesis" (W7437)